What is MuscleBud?
Topical pain relieving cream based on gate theory, placebo effect and clinical evidence seen in the following references.
In summary, MuscleBud uses biotechnology in Vytrus Biotech’s groundbreaking ingredient Kannabia Sense, which is cannabis sativa callus (stem cell) lysate (info in 2nd section), along with traditional Australian bush medicine for anti-inflammation and analgesic found in Kunzea ambigua leaf/stem oil extract. This is layered into a magnesium chloride based massage cream. To create the heating effect so adored by MuscleBud users, we have chosen a natural ingredient, Vanillyl Butyl Ether. This particular ingredient harnesses placebo effect in users and feels like a heat pack is on the site of application.
The Science
for Kunzea Ambigua… you don’t have to read this, we did it for you.
Braithwaite I, Hunt A, Riley J, et al. Randomised controlled trial of topical kanuka honey for the treatment of rosacea. BMJ Open. 2015;5(6):e007651. doi:10.1136/bmjopen-2015-00765126109117Chen CC, Yan SH, Yen MY, et al. Investigations of kanuka and manuka essential oils for in vitro treatment of disease and cellular inflammation caused by infectious microorganisms. J Microbiol Immunol Infect. 2016;49(1):104-111. doi:10.1016/j.jmii.2013.12.00924582465
Ducane Kunzea Oil. Australian Therapeutic Goods Administration, Public Summary. Published 2015. Accessed February 22, 2021.
Ito H, Kasajima N, Tokuda H, Nishino H, Yoshida T. Dimeric flavonol glycoside and galloylated C-glucosylchromones from Kunzea ambigua. J Nat Prod. 2004;67(3):411-415.
Kasajima N, Ito H, Hatano T, Yoshida T. Phloroglucinol diglycosides accompanying hydrolysable tannins from Kunzea ambigua. Phytochemistry. 2008;69(18):3080-3086. doi:10.1016/j.phytochem.2008.03.00318439633
Khambay BP, Beddie DG, Simmonds MS. An insecticidal mixture of tetramethylcyclohexenedione isomers from Kunzea ambigua and Kunzea baxterii. Phytochemistry. 2002;59(1):69-71. doi:10.1016/s0031-9422(01)00410-111754946
Kunzea ambigua (Sm) Druce. Australian National Botanic Gardens Centre for Australian National Biodiversity Research (CANBR). Updated December 24, 2015. Accessed February 22, 2021.
https://www.anbg.gov.au/gnp/gnp8/kunz-amb.html
Kunzea ambigua (Sm) Druce. USDA, NRCS. 2021. The PLANTS Database (http://plants.usda.gov, 22 February 2021). National Plant Data Team, Greensboro, NC 27401-4901 USA. Accessed February 22, 2021.
Semprini A, Braithwaite I, Corin A, et al. Randomised controlled trial of topical kanuka honey for the treatment of acne. BMJ Open. 2016;6(2):e009448. doi:10.1136/bmjopen-2015-00944826832428
Semprini A, Singer J, Shortt N, Braithwaite I, Beasley R; Pharmacy Research Network. Protocol for a randomised controlled trial of 90% kanuka honey versus 5% aciclovir for the treatment of herpes simplex labialis in the community setting. BMJ Open. 2017;7(8):e017766. doi:10.1136/bmjopen-2017-01776628775197
Semprini A, Singer J, Braithwaite I, et al. Kanuka honey versus aciclovir for the topical treatment of herpes simplex labialis: a randomised controlled trial. BMJ Open. 2019;9(5):e026201. doi:10.1136/bmjopen-2018-02620131092654
Therapeutic Goods Administration, Australian Government Department of Health. Kunzea ambigua: proposed advisory statements for medicines; version 1.0. Published December 2012. Accessed February 25, 2021.
Thomas J, Narkowicz CK, Jacobson GA, Peterson GM. Safety and efficacy of kunzea oil-containing formulations for the management of psoriasis: a randomized, controlled trial. J Clin Pharm Ther. 2015;40(5):566-572. doi:10.1111/jcpt.1231130156327
Thomas J, Webb CE, Narkowicz C, et al. Evaluation of repellent properties of volatile extracts from the Australian native plant Kunzea ambigua against Aedes aegypti (Diptera: Culcidae). J Med Entomol. 2009;46(6):1387-1391. doi:10.1603/033.046.061919960685
Thomas J, Narkowicz C, Peterson GM, Jacobson GA, Narayana A. Randomised controlled trial of the treatment of pastern dermatitis with a formulation containing kunzea oil. Vet Rec. 2009;164(20):619-623. doi:10.1136/vr.164.20.61919448254
Tisserand R, Young R. Essential Oil Safety: A Guide for Health Care Professionals. 2nd ed. Churchill Livingstone/Elsevier; 2014.
Warnke PH, Becker ST, Podschun R, et al. The battle against multi-resistant strains: renaissance of antimicrobial essential oils as a promising force to fight hospital-acquired infections. J Craniomaxillofac Surg. 2009;37(7):392-397. doi:10.1016/j.jcms.2009.03.01719473851
Cannabis Stem Cell Lysate
all images and information courtesy of Vytrus Biotech Pty Ltd
Kannabia Sense
Plant Biotechnology at its finest, Kannabia Sense is an award winning new raw material with no cannabinoids, though full of terpenes, polyphenols and Short-Chain Fatty Acids. Excellent for skin with an exciting oxytocin release in the brain, within 10 minutes of application, via the Microbiota-Skin-Brain Axis.
IN VITRO
MODULATION OF THE MICROBIOTA-SKIN-BRAIN AXIS
Kannabia SenseTM activates the oxytocin production in keratinocytes. The activation is done through the in-situ postbiotic (bSN) activating oxytocin production through the skin microbiota to keratinocytes (kSN) and sensory neurons.
Image 1.1 above
IN VIVO
EMOTIONAL MODULATION
Kannabia SenseTM positively stimulates the brain pleasure areas 10 minutes after the application. 132 brain regions were analysed.
Image 1.2 above
*Functional Magnetic Resonance Imaging. Approved by an ethical committee at Hospital de la Fe (Valencia, Spain).
More Science
Kim, Y. N., Sim, K. S., Park, S., Sohn, H., Kim, T., & Kim, J. H. (2022). In Vitro and In Vivo anti-inflammatory effects of Cannabis sativa Stem extract. Journal of Medicinal Food, 25(4), 408-417. https://doi.org/10.1089/jmf.2021.k.0200
Chaiwangrach, N., Waranuch, N., Temkitthawon, P., Wongwad, E., Nuengchamnong, N., Usuwanthim, K., Saesong, T., Rakkhetkorn, Y., Pisutthanan, S., & Ingkaninan, K. (2024). Quality assessment, stability and in-vitro anti-inflammatory activities of a topical ointment containing cannabis extract for haemorrhoids and skin diseases. https://doi.org/10.2139/ssrn.4720180
Mnekin, L., & Ripoll, L. (2021). Topical use of cannabis sativa L. Biochemicals. Cosmetics, 8(3), 85. https://doi.org/10.3390/cosmetics8030085
Ross, I. A. (2023). Cannabis and the skin. Plant-Based Therapeutics, Volume 1, 569-628. https://doi.org/10.1007/978-3-031-35155-6_12
Zagórska-Dziok, M., Bujak, T., Ziemlewska, A., & Nizioł-Łukaszewska, Z. (2021). Positive effect of cannabis sativa L. Herb extracts on skin cells and assessment of cannabinoid-based Hydrogels properties. Molecules, 26(4), 802. https://doi.org/10.3390/molecules26040802